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Dual DDR1 and DDR2 inhibitor 5n

CAS No. 2241813-33-0

Dual DDR1 and DDR2 inhibitor 5n( —— )

Catalog No. M13594 CAS No. 2241813-33-0

Dual DDR1 and DDR2 inhibitor 5n is a highly potent, selective, dual Discoidin domain receptor DDR1 and DDR2 inhibitor with Kd of 7.9 and 8.0 nM, IC50 of 9.4 and 20.4 nM, repectively.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    Dual DDR1 and DDR2 inhibitor 5n
  • Note
    Research use only, not for human use.
  • Brief Description
    Dual DDR1 and DDR2 inhibitor 5n is a highly potent, selective, dual Discoidin domain receptor DDR1 and DDR2 inhibitor with Kd of 7.9 and 8.0 nM, IC50 of 9.4 and 20.4 nM, repectively.
  • Description
    Dual DDR1 and DDR2 inhibitor 5n is a highly potent, selective, dual Discoidin domain receptor DDR1 and DDR2 inhibitor with Kd of 7.9 and 8.0 nM, IC50 of 9.4 and 20.4 nM, repectively; displays significant selectivity against a panel of 403 wild-type kinases at 1 uM (Abl1 IC50=494 nM); dose-dependently inhibited lipopolysaccharide (LPS)-induced interleukin-6 (IL-6) release in mouse primary peritoneal macrophages (MPMs), attenuates lung pathophysiologic changes in LPS-challenged mice, effectively decreases the levels of TNF-α and IL-6 both in BALF and serum.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Tyrosine Kinase
  • Target
    DDR
  • Recptor
    DDR
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2241813-33-0
  • Formula Weight
    560.625
  • Molecular Formula
    C31H31F3N6O
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    CC(C)C1=C(C=C(C=C1)C(=O)NC2=CC(=CC(=C2)C(F)(F)F)CN3CCN(CC3)C)C#CC4=CN=C5N4C=CN=C5
  • Chemical Name
    3-(Imidazo[1,2-a]pyrazin-3-ylethynyl)-4-isopropyl-N-(3-((4-methylpiperazin-1-yl)methyl)-5-(trifluoromethyl)phenyl)benzamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Wang Z, et al. J Med Chem. 2018 Aug 3. doi: 10.1021/acs.jmedchem.8b01045.
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